• Systimmune
  • $99,500.00 -168,590.00/year*
  • Redmond, WA
  • Scientific Research
  • Full-Time
  • 8839 166th Avenue Northeast

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Cell Line Development: Scientist/Senior Scientist

Located in Redmond WA, Systimmune Inc. is a bio-pharmaceutical company focused on the treatment of cancer through developing novel therapeutic multi-specific antibodies, as well as antibody-drug conjugates (ADC's). Our objective is to create biologics that work through systematic intervention on the solid tumor micro-environment, to either directly attack the tumor and/or to activate the immune system to attack the tumor.

We are seeking a talented Scientist / Senior Scientist in developing CHO cell lines for the production of biotherapeutics, with broad expertise, capable of contributing to both drug discovery and development projects. The position requires strong interest in bench work and deep background in cell line development for biologics. Experience working with multi-specific, fusion proteins are highly preferred.

Essential Duties and Responsibilities:
Lead and participate in cell line development activities
Hands on and independently generate CHO cell lines of high productivity and quality, continually improves the process
Ability to work in a high paced team environment, plan and meet timeline.
Responsible to prioritize work on multiple projects, support and closely work with other divisions to advance company goals
Drive cell line innovation to enhance the cell line platform to increase cell productivity and shorten cell line development timelines
Responsible for candidate optimization, selection, and validation
Conduct molecular biology studies to construct or modify expression vectors, genetically characterize cell line and analyze for sequence variants
Evaluate signal peptides for CHO expression system and familiar with CHO expression vectors
Provide technical leadership to project teams within area of expertise and commit resources to execute specific project tasks
Use of modern technologies for enrichment of recombinant cells and cell cloning, clonality determination; clone screening using automated systems
Present findings and results to senior management, external stakeholders, and industry peers at conferences
Understand regulatory requirements of the production cell lines for biotherapeutics
Provide mentoring to direct reports and guide their career development
Commit to write SOPs and reports, authors corresponding sections for regulatory filling
Strong ability to prioritize workload
Work with R&D and manufacturing department in China. Plan time to accommodate meetings and technical support with team members in China
Participate in timeline planning and decision making regarding research priorities of company or department and provide information on feasibility of prospective projects.
Other duties as assigned.

Education and Experience:

PhD with 5+ years, or a MS with 10+ years of experience in cell line development, cell culture development and related areas
Previous hands on experience in cell culture with a focus on mammalian cell recombinant protein production
Strong scientific understanding of recombinant protein expression, cell line development, cellular metabolism and media optimization
Experience in managing a team with an understanding of existing and emerging technologies in the cell line space and CMC, quality, and Regulatory considerations
Experience in early and late-stage biologic development
Excellent communication skills and a proven track record of publications and presentations

SystImmune is a stable, well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company s success. SystImmune offers a comprehensive benefits package including; 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 10 paid holidays and MORE.

SystImmune is an Equal Opportunity Employer. Interested applicants should send their CV and cover letter.

Associated topics: bacteria, biopharmaceutical, cytometry, dietician, kinesiology, medical, microbiological, pharmacology, pharmacy, virus

* The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.

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